By Colin MacInnes
London, 1958 - Soho, Notting Hill ... a global of smoky jazz golf equipment, espresso bars and hip hang-outs within the middle of London's rising early life tradition. The younger and stressed - absolutely the rookies - have been making a global as diverse as they dared from the normal snapshot of England's eco-friendly and delightful land. keep on with our younger photographer as he files the moments of a tender teenager's existence within the capital- intercourse, medicinal drugs and rock 'n' roll, the period of the 1st race riots and the lead-up to the swinging sixties. A 20th century cult vintage, Absolute novices is still the fashion bible for a person attracted to Mod tradition and paints a vibrant photograph of a altering society with perception and sensitivity.
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1990). Leukotriene B4 is thought to participate in myelopoiesis either direct1y or via the induction of cytokines and growth factors (Rola-Pleszczynski and Stankova, 1992). Nanomolar quantities of LTB 4 induce production oflL-6 by human monocytes (RolaPleszczynski and Stankova, 1992). Because of such diverse biological effects on various cell types, the precise mechanisms of eicosanoid action are not weil characterized. , 1983; Samuelsson, 1983). It is weil known 39 Table 2. Effeets of araehidonic aeid-derived prostaeyclin and prostaglandins on the growth of a variety of eells in eulture Stimulates PGA2 No effeet Inhibits Referenee Friend erythro1eukemia2 (m) L-1210 leukemia (m) HeLa ovarian eare.
Control cells exhibited a 5-fold increase in cell number. Points, mean values relative to control for 3 separate experiments each set up in triplicate wells; bars, SE. Statistical significance was assessed by a paired Student's t test on the raw data from a11 three experiments. OI: LNA 24-30 ILM, EPA 12-30 ILM, DHA 12-30 ILM, AA 18-30 ILM. Reproduced from Grammatikos er al. (I 994b) with permission. , 1979). , 1994b). All of the n-3 FAs inhibited MCF-7 cell growth in a dose-dependent manner, with EPA and DHA being most effective (Fig.
4 22:6 22:5 ( 4, 7, 10, 13, 16) Fig. 2. I>HA ( 4, 7, 10, 13, 16, 19) Metabolism of the paren! essential fatty acids linoleic (n-6) and a-linolenic (n-3) to other fatty acids of the same family. The positions of the double bonds, relative to the carboxyl end, are shown in parentheses for each fatty acid. , 1981). Given the great diversity in the ability of cultured ceHs to process EFAs, the intraceHular fate of exogenous EFAs is central to any investigation of their biological roles, and must be evaluated.