By F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio (auth.), Prof. G. Mathé, Dr. G. Bonadonna, Prof. S. Salmon (eds.)
Transplantation of syngeneic (donor is a monozygous dual) or allogeneic (donor is an HLA-identical sibling) marrow offers the chance for competitive antileukemic remedy with no regard to marrow toxicity. until eventually 1975, marrow transplantation was once conducted merely after failure of all different treatment. for that reason, such a lot sufferers have been in complex relapse. Six of sixteen recipients of syngeneic marrow and thirteen of a hundred recipients of allogeneic marrow are nonetheless in remission after five. 5-10 years [3, 7]. An actuarial survival curve of the 1st a hundred sufferers grafted in Seattle after conditioning with cyclophos phamide (60 mg/kg on every one of two successive days) and overall physique irradiation (1,000 rad) confirmed 3 classes of curiosity: (1) the 1st four months confirmed a speedy lack of sufferers linked to complicated disorder, graft-versus-host ailment, infections (in specific interstitial pneumonias), and recurrent leukemia; (2) from four months to two years, the curve confirmed a far slower cost of decline attributable basically to recurrent leukemia; and (3) from 2-10 years, the curve was once virtually flat with a negligible lack of sufferers and no recurrent leukemia. This flat component to the curve corresponded to thirteen% of the sufferers and shows a powerful likelihood that most of those survivors are cured in their illness . makes an attempt at lowering the occurrence of leukemic relapse after transplantation have been made via a few marrow transplant teams by way of further chemotherapy.
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G (1) ... o 9 (1) a Q (1) '"~2" ::s ...... ::s 0::s ;l;> 32 J. L. Misset et al. ), and on days 3 -10, prednisone (40 mg/m2 orally). Patients are randomized to receive Azimexon or not (130 mg/m2 orally) on days 20 and 22 after each reinforcement course. Systemic therapy with 6-MP, MTX, and VDS is resumed after reinforcement as soon as bone marrow recovery permits. Any treatment must be interrupted after 3 years of continuous CR. Patients This protocol was given to 34 patients whose ages, sex, and diagnoses are presented in Table 1.
G. Bekesi and J. F. Holland City University of New York, The Mount Sinai School of Medicine and Hospital, Department of Neoplastic Diseases, New York, NY 10029, USA Summary Our chemoimmunotherapy study shows significantly longer remission and survival in acute myelocytic leukemia (AML) patients who have been immunized with neuraminidase-treated allogeneic myeloblasts as compared to patients who received chemotherapy alone or neuraminidase-treated myeloblasts plus MER. MER impairs the immunotherapeutic effectiveness of neuraminidase-treated allogeneic myeloblasts in AML patients.
Brachytherapy is a low dose-rate continuous radiation. This type of localized radiation can also be used at a low level as an adjuvant therapy. In adenocarcinomas of uterine corpus the treatment is a total hysterectomy, which shows 15-20% local recurrence in the vaginal cavity. A dose of 50 Gy delivered post- or preoperatively at the upper half of the vaginal cavity decreases the risk of local recurrence to less than 3% . In neurosarcomas of the limbs, there is a very high frequency of recurrence after surgery.