Cancer

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By George F. Vande Woude

Advances in melanoma study presents helpful details at the intriguing and fast-moving box of melanoma examine. the following, once more, amazing and unique reports are provided on quite a few issues

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Extra resources for Advances in Cancer Research, Vol. 107

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The Clinical Effect of a Single Injection Versus Repeated Injections of Low-Dose CYC at Different Time Intervals The kinetics of suppressor T cell depletion following low-dose CYC administration was described in several studies (summarized in Table I). The results differ according to whether normal mice, tumor-bearing rodents, or advanced cancer patients were tested. In normal mice Treg reduction began after 1–2 days, with the lowest decrease at 4–6 days, and this was restored to a normal level at 10–14 days (in one study the levels were monitored for 4 weeks and were still low).

J. Exp. Med. 202, 1507–1516. , Putnam, A. , Szot, G. , Lee, M. , Gottlieb, P. , Gingeras, T. , Soper, D. , et al. (2006). CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4þ T reg cells. J. Exp. Med. 203, 1701–1711. Liu, J. , Zhang, X. , Yang, J. , Li, H. , Mao, Y. , Li, Y. , Xia, J. , and Zeng, Y. X. (2007). Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine. Cancer Immunol. Immunother. 56, 1597–1604. Liyanage, U.

OX40 costimulation can abrogate Foxp3þ regulatory T cell-mediated suppression of antitumor immunity. Int. J. Cancer 125, 630–638. Kronenberg, M. (2005). Toward an understanding of NKT cell biology: Progress and paradoxes. Annu. Rev. Immunol. 23, 877–900. , and Katsanis, E. (2007). Tumor-derived CD4(þ)CD25(þ) regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10. Cancer Immunol. Immunother. 56, 48–59. , and Haran-Ghera, N. (2008). Increased regulatory versus effector T cell development is associated with thymus atrophy in mouse models of multiple myeloma.

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