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Adapted with permission from reference 14. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. ch003 Tissue and cells structures were identified in histological sections by staining with Verhoeff s tissue elastin stain. Neointimal and medial cross-sectional areas were measured by computer-assisted digital planimetry. For stented arteries, values from proximal, mid, and distal sections were averaged. A l l data are presented as meaniSD. Statistical comparisons were performed with a one-way A N O V A utilizing the least significant difference methods for multiple comparisons versus control.
N Engl J Med 1999, 340,115-26. 20. Ross, R. Adv Nephrol Necker Hosp 1990, 19,79-86. 21. Ross, R. J Am Geriatr Soc 1983, 31,231-5. 22. Clowes, A . , Reidy, M. A . & Clowes, M. M. Lab Invest 1983, 49,208-15. 23. Clowes, A . W . & Schwartz, S. M. Circ Res 1985, 56,139-45. 24. Ross, R. & Glomset, J. A . N Engl J Med 1976, 295,369-77. 25. Ross, R. & Glomset, J. A . N Engl J Med 1976, 295,420-5. 26. Mosse, P. , Campbell, G. R. & Campbell, J. H . Arteriosclerosis 1986, 6,664-9. 27. Mosse, P. , Campbell, G.
Leukocyte Adhesion One of the earliest events in the response is the adhesion of inflammatory cells to the site of endothelial injury. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. ch002 21 selectins; (ii) adhesion triggered by cytokines; (iii) strong adhesion and (iv) chemotactic migration of the leucocyte . Heparin's role in leucocyte adhesion may be three fold. First it may inhibit the expression of the cytokines which induce the initial adhesion . Second, it may bind to those cytokines preventing their attachment to the luminal surface (43).