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Additional resources for Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases)
Ganglion, amacrine, and photoreceptor cell of the retina expressed MT1 and MT2. The expression of both receptor was decreased in AD retina. MT1 and MT2 were also localized in the pineal gland and occipital cortex. In the pineal gland both MT1 and MT2 were localized to pinealocytes, whereas in the cortex both receptors were expressed in some pyramidal and non-pyramidal cells. In patients with AD, parallel to degenerative tissue changes, there was an overall decrease in the intensity of receptors in both brain regions.
E. J. C. Petersen 1 2 Department of Neurology, Department of Radiology, Mayo 3 Clinic, Rochester, MN, Department of Neurogenetics, 4 5 Department of Neurology, Department of Neuropathology, 6 Mayo Clinic, Jacksonville, FL, Department of Laboratory 7 Medicine and Pathology, Department of Psychiatry and 8 Psychology, Robert H. and Clarice Smith and Abigail Van Buren Alzheimer S Disease Research Program, Mayo Clinic, Rochester, MN, USA Background & Aims: To report MRI findings in affected members of eight kindreds having mutations in progranulin (PGRN) associated with frontotemporal dementia and parkinsonism (FTDP).
Design/Methods: We analyzed all available clinical, radiologic, genetic, and pathologic data in individuals of the F142 kindred evaluated at our center. Results: Eight individuals in two generations became symptomatic. Clinical material was available in four in generation 1 (G1) and three in generation 2 (G2). Mean age of onset in G1 was 69 years (range 69-80), and 61 years in G2 (range 51-66). 0 years (range 1-7) in G2, with those in G2 still living. Clinical diagnoses included mild cognitive impairment, Alzheimer's disease, frontotemporal dementia, primary progressive aphasia, and corticobasal syndrome; some diagnoses changed during the clinical course, and some carried overlapping diagnoses.