By Prof. Dr. U. Trendelenburg (auth.), Prof. Dr. Peter Riederer, Prof. Dr. Moussa B. H. Youdim (eds.)
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Additional info for Amine Oxidases and Their Impact on Neurobiology: Proceedings of the 4th International Amine Oxidases Workshop, Wurzburg, Federal Republic of Germany, July 7–10, 1990
1980). The 3Kb MAO-B transcript was not detectable in the placenta under our experimental conditions which confirmed findings by Egashira and Yamanaka (1981). It is interesting to note that the small intestine had the highest level of both MAO-A and B transcript. This enzyme may play an important role in peripheral tissues. The presence of the 2Kb transcript in these two tissues suggests that MAO-A may be rapidly synthesized to meet the needs of the body. The hybridization of the Hind III-Sail fragment to placental and adult brain RNA was used to elucidate the difference between the 5Kb and 2Kb MAO-A transcript.
Use of llC has the advantages of lower total radiation exposure with better imaging. Furthermore, the physiological dopamine precursor, rather than a substitute analogue, is used. In-vivo PET imaging of catecholaminergic neuronal function 23 Imaging peripheral sympathetic innervation Amine uptake by sympathetic nerve terminals was first discovered over twenty-five years ago when it was found that a major portion of 3H-norepinephrine administered to animals was retained in those tissues which have high endogenous concentrations of norepinephrine.
It can be speculated that alterations on the level of the so called third messengers are important for the mechanism of action of antidepressants, too. Today, it is an open question in which precise neuronal processes these genes are regulated. The application of molecular biological methods promises new insights into the mechanism of action of drugs. References Aghajanian GK, Sprouse JS, Rasmussen K (1987) Physiology of the midbrain serotonin system. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress.