Download Antihypertensive Therapy: Principles and Practice an by C. Bartorelli (auth.), F. Gross (eds.) PDF

By C. Bartorelli (auth.), F. Gross (eds.)

Hypertension has definitely been one of many issues such a lot fre­ quently mentioned at symposia, conferences, and congresses in the course of contemporary years. there's a number of purposes for this; 3 of them are noticeable: to start with, the truth that a wide share of the world's inhabitants is struggling with a number of different types of hypertensive disorder; secondly, expanding wisdom of the pathogenesis of high blood pressure and of the disturbances underlying it; and, thirdly, the marked development which has been made in antihypertensive remedy over the last fifteen years. while plans for the current symposium have been being drawn up, it was once felt that it's going to no longer easily bring on simply one other assembly on high blood pressure, yet may still position specific emphasis on these elements which had no longer been competently mentioned at earlier symposia of this sort. apparently sufficient, the subject which looked as if it would have acquired least consciousness long ago used to be remedy, even though from the sensible perspective this is often via some distance an important. the alternative of remedy because the major subject of the complete symposium additionally appeared to be warranted in view of the quite lengthy interval that had elapsed when you consider that powerful antihyper­ tensive therapy grew to become on hand; the time had in reality come now to judge the advantages in addition to the shortcomings of drug remedy as on hand today.

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There are, however, instances of true escape of the renal tubules from the inhibitory action of benzothiadiazines on sodium reabsorption. The results of an experiment on a group of 14 rats receiving an intravenous infusion of isotonic saline at a rate sufficient to maintain a positive sodium and water balance throughout the experiment are shown in Fig. 3. fkg. ) Fig. 3. Escape from the natriuretic effect of hydrochlorothiazide In rats. · min. Nosignl/lcant changes in diuretic response or glomerular ftItratlon rate were noted In the control group within 7 hours.

In 1952, BARRETT et a1. showed that, in the heart-lung preparation of the dog, hydralazine potentiates the coronary dilator action of adrenaline. The influence of hydralazine on the myocardium and coronary circulation was investigated recently by BARRETT et a1. (1965) and BRUNNER et a1. (1965a, b). The increase in both myocardial contractility and coronary flow produced by hydralazine could be inhibited by adrenergic fJ-receptor blockade. ABBOUD and ECKSTEIN (1962) concluded from experiments on dogs that guanethidine would produce vasodilatation by stimulation of fJ-adrenergic receptors or other dilator receptors which are blocked by dichloro-isoprotereno1.

A. HUGGINS, and R. A. WOODBUBY: J. Pharmacal. Exper. Therap. 89, 271 (1947). -BARRETT, W. , H. POVALSKI, and R. RUTLEDGE: Fed. Proc. 24, 712 (1965). PLUMMER, and F. F. N: Fed. Proc. 11, 320 (1952). - BEIN, H. : In: Pharmacology of Oriental Plants. Proc. 2 nd Internat. Pharmacol. Meeting, Prague, 1963. Ed. by K. K. CHEN and B. MUKERJI. Czechoslovac Medical Press, Prague, 1965, 7, p. BEIN, H. , P. A. DESAULLES, and P. LoUSTALOT: Experientia 13, 130 (1957). - BEIN, H. , F. GROSS, J. TRn>OD, and R.

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