By M. A. Koch, H. Waldmann (auth.), W. Wohlleben, T. Spellig, B. Müller-Tiemann (eds.)
Genome- and proteome-based learn is producing an important bring up within the variety of to be had drug goals. Correspondingly there's an expanding want for novel, assorted compounds, quite in accordance with normal compounds, as screening source. the aim of the Ernst Schering learn starting place Workshop 51 used to be to supply a discussion board for an open alternate on views and obstacles of biocombinatorial synthesis and the importance of this expertise for destiny drug discovery in gentle of this problem. specialists from academia and supplied contributions protecting: the importance of normal compounds for state of the art drug discovery; the underlying uncomplicated precept for the biosynthesis of hugely complicated compounds; and the scope and obstacles of combinatorial biosynthesis relating to formation, id, optimisation, isolation and production of novel biologically lively entities.
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Extra info for Biocombinatorial Approaches for Drug Finding
46 47 49 50 50 54 54 58 59 61 62 63 65 69 70 71 After a decade in which the pharmaceutical industry lost interest in natural products, there is a renewed appreciation for the intrinsic utility of these compounds in lead discovery (Rouhi 2003). g. g. g. g. FK506 and rapamycin) and many other types of therapeutics. In 44 K. J.
1 The Search for New Drug Leads After the discovery of the first antibiotics produced by microorganisms, systematic programmes were undertaken, aimed at the discovery of antibiotics from microbial sources. The result of these screening activities is the large number of compounds that have found applications in human medicine and agriculture.
Developing Tools for Strain Isolation . . Exploiting the Uncultured World . . . . Accessing Uncultured Actinomycetes . . Genetic Potential of Novel Strains . . . Integrating Tools for Bioprospecting . . Outlook . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 The Search for New Drug Leads After the discovery of the first antibiotics produced by microorganisms, systematic programmes were undertaken, aimed at the discovery of antibiotics from microbial sources.