Organic Chemistry

Download Bioorganic Chemistry of Biological Signal Transduction by Herbert Waldmann, G. Dorman, P.J. Hergenrother, C. Herrmann, PDF

By Herbert Waldmann, G. Dorman, P.J. Hergenrother, C. Herrmann, J. Kuhlmann, A. Levitzki, S.F. Martin, G. Müller, M. Thutewohl, H. Waldmann

A variety of the main complex themes in bioorganic and medicinal chemistry of sign transduction. the subjects mentioned are vital to fields similar to biology, biochemistry, medicinal chemistry, and artificial natural chemistry. this article can also be on hand electronically at an internet tackle provided with the textual content.

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Relatives of Ras . . . . . . Other Members of the Ras Subfamily Rho Subfamily . . . . . . . Rab and Arf Subfamilies . . . . Ran . . . . . . . . . . 2 Biophysical Methods . . . . . . . . . . . . . 77 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Readout for Biological Macromolecules . . . 2 Radioisotopes . . . . . . . . . . 3 Staining Techniques . . .

Researchers at Glaxo described a-dicarbonyl moieties attached to the 4position of the phenyl ring of Phe as non-charged phosphate mimics 24, 25 that turned out to be two to three orders of magnitude less active when compared to a corresponding pTyr analogue in the Src SH2 domain binding assay [129]. Oxamic acid 26 and N-hydroxyoxamic acid 27 derivatives were disclosed by the Boehringer Ingelheim group as moderately active Lck SH2 domain antagonists [119, 130]. 36 G. 4 Dicarboxylic Acids A further step towards increasing the spatial density of oxygen functionalities was made by introduction of various malonyl-derivatives such as OMT 28 [O-(2malonyl)tyrosine], or FOMT 29 [O-(2-(2-fluoromalonly))tyrosine] (Scheme 4) [131–133].

62 64 64 66 66 67 70 73 73 74 75 75 77 77 77 78 78 Topics in Current Chemistry, Vol. 211 © Springer-Verlag Berlin Heidelberg 2000 62 J. Kuhlmann · C. 5 UV/Vis Spectroscopy . . . . . 6 Fluorescence-Based Assays . . . 7 Surface Plasmon Resonance . . . 8 Circular Dichroism . . . . . 2 Equilibria . . . . . . . . 2 Fluorescence Titration . . . . 3 Isothermal Titration Calorimetry . 3 Kinetic Analysis .

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