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Download Breast Cancer Management and Molecular Medicine by Martine J. Piccart, William C. Wood, Chie-Mien Hung, PDF

By Martine J. Piccart, William C. Wood, Chie-Mien Hung, Lawrence J. Solin, Fatima Cardoso

Molecular-based medication is taking heart level because of the expanding wisdom of breast melanoma molecular biology. remedy tailoring is not any longer a dream for the longer term, however the major objective of present research.

This e-book presents an summary of the newest ideas, brokers and methods for breast melanoma that give a contribution to the individualization of remedy. present biomedical study makes a speciality of facilitating the move of molecular biology wisdom into the medical administration of sufferers, resulting in elevated survival in addition to stronger caliber of existence. specific realization is given during this ebook to organ-specific adapted ways, particular populations, sufferers’ personal tastes and rehabilitation. additionally mentioned extensive are the respective roles of pharmacotherapeutics modelling, useful imaging, molecular staging, genomics and proteomics and their impression at the "re-classification" of breast melanoma, in addition to the scientific functions of uncomplicated technological know-how. The the most important factor of ways to optimally combine organic markers, new applied sciences and new diagnostic and healing techniques into medical trials and medical perform is addressed.

Combining the contributions from authors who're popular specialists in those fields with editorial reviews, this e-book presents an outline of the most recent achievements in breast melanoma and their use in scientific practice.

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8 Adjuvant Chemotherapy . . . . . . . . . . . Metastatic Disease . . . . . . . . . . . . . . Hormonal Therapy . . . . . . . . . . . . . . Chemotherapy . . . . . . . . . . . . . . . Immunohistochemical Differences Between Male and Female BC . . . . . . . . HER-2 expression . . . . . . . . . . . . . . Cell-Cycle Regulatory Proteins . . . . . . . . Androgen-Regulated Proteins . . . . . .

The Use of ERT/HRT in Women with a Previous Diagnosis of Breast Cancer . . Treatment Alternatives . . . . . . . . . . . . Osteoporosis, Colon Cancer, Genitourinary Symptoms, Alzheimer’s Disease, Vasomotor Symptoms . . . . . . . . . . . . . . . . . . Osteoporosis . . . . . . . . . . . . . . . . Coronary Artery Disease . . . . . . . . . . . Colon Cancer . . . . . . . . . . . . . . . . Genitourinary Symptoms . .

Membrane-Initiated Steroid Signaling . . . . . PRs A and B . . . . . . . . . . . . . . . . . Future Directions . . . . . . . . . . . . . . Acknowledgements . . . . . . . . . . . . . 4 Introduction . . . . . . . . . . . . . . . . Novel Insights into the ErbB Family of RTKs . . Overview of the ErbB Signaling Pathway . . . . Akt Promotes Tumor Survival . . . . . . . . Keeping p21Cip1/WAF1 out of the Nucleus .

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