Cancer

Download Cancer Drug Discovery: Science and History by Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim PDF

By Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim

The reader will find a finished and multifaceted assessment of the heritage of the advance of anticancer medicinal drugs deeply encouraged by means of the cellphone suggestion of melanoma and destiny instructions for the advance of latest anticancer medicinal drugs. First, this publication files the clinical growth in organic technology over the past 70 years and the impression this growth had in melanoma study. Summaries and charts of significant discoveries entire this evaluate. additionally, this ebook outlines the method of anticancer drug improvement with a spotlight at the attribute drug teams of every period, on the topic of developments of chemistry and organic sciences. This booklet additionally offers short mechanism of motion of substances, illustrated through entire timelines and conceptual cartoons. This publication ultimately sums up the constraints of the present anticancer drug improvement and seeks new instructions for anticancer drug discovery, contemplating below the systemic view of cancer.

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These expectations led to various studies on the gene mutations of human cancers using the rapid genomic DNA sequencing technology. In 2004, a year after the discovery of the human genome sequence, B. Vogelstein [74] proposed the theory that cancer is in essence a genetic disease. The Cancer 2 Advancement of the Science and History of Cancer and Anticancer Drugs Fig. 10 Molecular targeted anticancer drugs Fig. 2 Number of mutations in human cancers Adult cancer Small cell lung cancer Non-small cell lung cancer Melanoma Esophageal squamous cell carcinoma Non-Hodgkin lymphoma Head & neck cancer Colorectal cancer Esophageal adenocarcinoma Gastric cancer Endometrial cancer Pancreatic cancer Ovarian cancer Prostate cancer Hepatocellular cancer Glioblastoma Breast cancer Chronic lymphocytic leukemia Acute myeloid leukemia Pediatric cancer Glioblastoma Neuroblastoma Acute lymphocytic leukemia Medulloblastoma Rhabdoid cancer No.

In the bioscience field in the 1960s, S. Brenner, F. Jacob, and M. Meselson discovered mRNA, which mediates the transfer of genetic information from DNA to protein (1961) [24]. In the early 1960s, M. Nirenberg and H. G. Khorana deciphered the genetic code that explained the pathway of expression of the genetic information—the DNA-mRNA-protein chain [25, 26]. The revelation of the true nature of genetic information and the process of expression of this information to protein elucidated the relationship among genetic information and intracellular functions, various life phenomena, and carcinogenesis.

Jacob M. Meselson Deciphering the genetic code M. Nirenberg G. Khorana Discovery of interferon inhibiting viral replication A. Isaacs J. Lindemann “Central Dogma”: DNA → RNA → Protein F. P. Burkitt Treatment of choriocarcinoma with methotrexate: first cure of a solid tumor R. C. L. Noble Development of 5-fluorouracil C. Heidelberger 2 Advancement of the Science and History of Cancer and Anticancer Drugs 47 1972 [1971–1980] 1970 Recombinant DNA P. O. Smithies Discovery of retrovirus D. M. Temin 1971–1984 1971 1970 The National Cancer Act R.

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