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Download Chaperones: 16 by Ville Hietakangas, Lea Sistonen (auth.), Ineke Braakman PDF

By Ville Hietakangas, Lea Sistonen (auth.), Ineke Braakman (eds.)

Molecular chaperones engage with almost each newly synthesized protein. Their function isn't constrained to this, as increasingly more protein-protein interactions are came across to be mediated by way of molecular chaperones. They stay in huge complexes, in each mobile compartment, and to some degree even outdoor cells. those proteins are of curiosity to numerous scientists, not just to these drawn to protein biosynthesis, but in addition when it comes to protein shipping, organelle biogenesis, and phone pressure.

Whereas first-class studies on molecular chaperones are released, they typically specialise in the most recent effects with no reiterating the fundamentals. The target of this quantity used to be to gather a set of stories on molecular chaperones that might be either well timed and simple, which might lead them to a great front for newcomers into the sphere and appropriate for instructing purposes.

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Melanogaster is transcriptionally engaged. Cell 54:795-804 Sakahira H, Breuer P, Hayer-Hartl MK, Hartl FU (2002) Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci USA 99 Suppl 4:16412-16418 Sandqvist A, Sistonen L (2004) Nuclear stress granules: the awakening of a sleeping beauty? J Cell Biol 164:15-17 Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI (1991) Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

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Genes Dev 15:2134-2145 Alastalo TP, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M (1998) Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat Seminiferous epithelium. Exp Cell Res 240:16-27 Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L (2003) Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. J Cell Sci 116:3557-3570 Ali A, Bharadwaj S, O’Carroll R, Ovsenek N (1998) HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes.

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