By Brehon Laurent
This quantity contains well timed stories of numerous features of chromatin biology written through scientists on the vanguard of this quickly relocating box. subject matters lined comprise the constitution and serve as of protein modules inside of chromatin-remodeling proteins, newly characterised histone transformations (methylation, ubiquitylation) and their sensible results, transcription and histone dynamics, roles of chromatin home improvement components in DNA replication and service, and present types of nucleosome-remodeling mechanisms.
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Additional info for Chromatin dynamics in cellular function
Illustration of the known effector proteins of methylated histones shown above their cognate methyl lysine binding sites on the histone H3 and H4 tails. S. A. Grant created when H3 K9 was methylated in what is referred to as an “aromatic cage” (Fischle et al. 2003; Jacobs and Khorasanizadeh 2002). These studies support earlier ﬁndings that H3 K9Me targets the silencing protein, HP1, to heterochromatin (Bannister et al. 2001; Lachner et al. 2001; Nakayama et al. 2001). Interestingly, HP1 may form homodimers and subsequently compact chromatin into higher order heterochromatin structures when bound to histone H3 K9Me (Thiru et al.
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