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Chapter 1 The Lysosome suggestion (pages 1–35): Christian de Duve
Chapter 2 Lysosomes within the body structure and Pathology of Cells: Contributions of Staining equipment (pages 36–77): Alex B. Novikoff
Chapter three Lysosomes: Distribution in Animals, Hydrolytic ability and different houses (pages 78–113): A. L. Tappel, P. L. Sawant and S. Shibko
Chapter four a few Observations at the incidence and Nature of Esterases in Lysosomes (pages 114–125): S. J. Holt
Chapter five The Cytoplasmic Granules of Phagocytic Cells and the Degradation of micro organism (pages 126–150): Zanvil A. Cohn, James G. Hirsch and Edith Wiener
Chapter 6 Dynamics of Adrenal functionality in guy (pages 151–175): Peter H. Forsham, Vincent Di Raimondo, Donald Island, Arthur P. Rinfret and Richard H. Orr
Chapter 7 impression of the Injection of Triton Wr?1339 at the homes of Rat?Liver Lysosomes (pages 176–200): R. Wattiaux, M. Wibo and P. Baudhuin
Chapter eight high quality constitution and Enzymic task of Protozoan foodstuff Vacuoles (pages 201–225): M. Muller, P. Rohlich, J. Toth and that i. Toro
Chapter nine The Relation to Lysosomes of the In Vivo Metachromatic Granules (pages 226–263): A. M. Dalcq
Chapter 10 houses and position of Acid Hydrolases of the Mullerian Ducts in the course of Sexual Differentiation within the Male Chick Embryo (pages 264–281): Denise Scheib
Chapter eleven Behaviour and homes of Acid Hydrolases in Regressing Tails of Tadpoles in the course of Spontaneous and triggered Metamorphosis In Vitro (pages 282–310): Rudolf Weber
Chapter 12 Lysosomal adjustments in the course of Liver damage and Mammary Involution (pages 311–335): T. F. Slater, A. L. Greenbaum and D. Y. Wang
Chapter thirteen Lysosome alterations in Liver harm (pages 335–361): Mario Umberto Dianzani
Chapter 14 The Reversible Activation of Lysosomes in common Cells and the results of Pathological stipulations (pages 362–383): Lucille Bitensky
Chapter 15 motion of diet A at the balance of Lysosomes In Vivo and In Vitro (pages 384–404): J. T. Dingle

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86, 11. HIRSCH, J. G. (1962). /. exp. , 116,827. HIRSCH, J. , BERNHEIMER, A. , and WEISSMANN, G. (1963). ]. cxp. , (in press). HIRSCH, J. , and COHN,Z. A. (1960). ]. exp. , 112, 1005. (1962). Franwurt. Z. , 71,498. KOENIG, H. (1962). ), 195, 782. , andJIBRIL, A. (1963). Bioclzirn. biophys. Acta, (in press). KUFF,E. , and DALTON,A. J. (1959). I n Subcellular Particles, p. 114, ed. Hayashi, T. New York: Ronald Press. F. , and BROWN, J. H. U. (1958). biophys. , . 4, 833. , and HERS,H. G. (1963).

LYSOSOMES AS PART OF THE INTRACELLULAR DIGESTIVE TRACT In an earlier review (de Duve, 19sgn), the possibility was considered that " the biochemical concept of lysosomes may cover several biologically and morphologically distinct entities, namely : (I) zymogen-like granules containing newly synthesized enzymes ; (2) pinocytosis vacuoles at various stages of their evolution; (3) LYSOSOMES--2 C. " Recent studies have greatly strengthened this view and have shown the existence of a fourth entity, presumably also obeying the definition of lysosomes, namely the autolytic vacuoles arising from the process of cellular autophagy which will be discussed in INTRACELLULAR DIGESTIVE TRACT RIBOSOMES y x xx x X X * ACID HYDROLASES CELL MEMBR A N E LYSOSmOMES C A L K C I lull !

D E D U V E acid phosphatase has in recent years provided a remarkable impetus to the study of the physiology and pathology of lysosomes, and will undoubtedly continue to do so. However, if we wish to retain the original definition of these particles, with all its functional implications, logical consistency requires that an object exhibiting only one of their characteristics, especially in a test which, even under the most favourable conditions, is never entirely free from artifacts, should not be declared a lysosome u prioui.

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