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By I. Chaikovsky, N. Sydorova

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2004). The success of a model including a GRS should be measured by its ability to help individuals and physicians in making decisions regarding lifestyle advice or pharmacological treatment in order to decrease CHD risk and disability. In this study, after multivariate logistic regression, the independent predictors of CHD were dyslipidemia, type 2 diabetes, hypertension, daily intake of alcohol and GRS. Although after multivariate logistic regression the risk of CHD determined by the GRS did not exceed that of conventional risk factors, this independent predictor based on genetic risk variants has some advantages.

C. (1998). Antioxidants and atherogenesis. Journal of Nutritional Biochemistry, 9, 424-445. ISSN 0955-2863 Sullivan, J. L. (1981). Iron and the sex difference in heart-disease risk. Lancet, 1, 1293-1294. ISSN 1293-1294 Suzuki, Y. , Park, A. M. & Day, R. M. (2006). Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radical Biology and Medicine, 40, 1683-1692. ISSN 0891-5849 Tan, K. C. , Chow, W. , Lam, J. C. , Wong, W. , Tam, S. & Ip, M.

Luckily our bodies are adapted to these constant changes, but only to a limited extent. Minor damage accumulates over the years. The fittest survive and we must be aware that not escaping natural selection, it continues to act upon us. An alert on the evaluation of data involving oxidative stress: strict criteria are needed. For example, studies of ascorbic acid supplementation in rats and mice should be evaluated very carefully since these species synthesize vitamin C, while humans do not. Extrapolation of this data type for the human species must be carefully evaluated if it is to have any value.

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