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Extra resources for Dermatologic Clinics (Infectious Diseases, Volume 21, Number 2, April 2003)
Moniliforme), and F. solani being the most frequently isolated [29,43]. In humans, Fusarium species can cause disease that is localized, focally invasive, or disseminated . Onychomycosis caused by Fusarium species—in particular F. oxysporum—features characteristic milky lesions [42,45]. The clinical patterns described include SWO, DLSO, and PSO . Though PSO is uncommon, Baran et al  found that the combination of PSO with subacute or acute paronychia in an immunocompetent individual is a typical manifestation of Fusarium nail invasion.
Cutis 1989;44:23 – 4.  Phair JP, Williams JE, Bassaris HP, et al. Phagocytosis and algicidal activity of human polymorphonuclear neutrophils against Prototheca wickerhamii. J Infect Dis 1981;144:72 – 6.  Padhye AA, Baker JG, D’Amato RF. Rapid identification of Prototheca species by the API 20C system. J Clin Microbiol 1979;10:579 – 82.  Moossavi M, Bagheri B, Scher R. Systemic antifungal therapy. Dermatol Clin 2001;19:35 – 52.  Beaman L. Fungicidal activation of murine macrophages by recombinant gamma interferon.
Purulent discharge from the proximal nail fold might also be present. Culture and microscopy In direct microscopy, Aspergillus infections show hyaline hyphae that are generally somewhat wider than dermatophyte hyphae. They also tend to bear irregular swellings and vesicles that are distinct from the regular chains of substrate arthroconidia produced in tissue by Table 3 Treatment of Fusarium onychomycosis Reference Study type No. of patients (evaluable) Fusarium spp Tseng et al, 2000  Case report 1 (1) De Doncker et al, 1997  Multicenter 1 (1) De Doncker et al, 1997  Multicenter 2 (2) Gupta et al, 2001  Open, prospective 1 (1) Gupta et al, 2001  Open, prospective 1 (1) F.